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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

FORMULATION AND EVALUATION OF SUMATRIPTAN SUCCINATE MICROSPHERES BY USING DIFFERENT POLYMERS

S. K. Ameena Farheen*, Dr. M. Dhanalakshmi and B. Veeru naik

ABSTRACT

In the present work, Microspheres of Sumatriptan Succinate using Sodium alginate, Chitosan, Eudragit as polymers were formulated to deliver Sumatriptan Succinate via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Sumatriptan Succinate microspheres. FT-IR spectra of the Drug and optimised revealed that the drug is compatible with the Excipients used. Micromeritic studies revealed that the mean particle size of the prepared microspheres and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Sumatriptan Succinate using sodium alginate as polymer adhered to the mucus to a greater extent than the microspheres of Sumatriptan Succinate using Chitosan as polymers. The invitro drug release decreased with increase in the polymer concentration. Analysis of drug release mechanism showed that the drug release from the formulations followed zero order kinetics. Based on the results of evaluation tests formulation coded T3 was concluded as best formulation.

Keywords: Sumatriptan Succinate, Sodium alginate, Chitosan, Eudragit, Microspheres.


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