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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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Abstract

DEVELOPMENT OF SIMPLE AND VALIDATED METHOD FOR THE QUANTITATIVE ESTIMATION OF MESALAMINE USING UV SPECTROSCOPIC METHOD

Kumar Raja Jayavarapu*, B. Sireesha, Ch. Maneesha, J. Sivanagadathu, K. Nagalakshmi, Y. Nikhil, Dr. T. Satyanarayana

ABSTRACT

Mesalamine is used to treat inflammatory bowel diseases including ulcerative colitis (or) inflamed anus (or) rectum and to maintain remission in crohn,s diseases. Mesalamine is a newer skeletal muscle relaxant and is used along with rest and physical therapy to decrease muscle pain and spasms associated with strains, sprains or other muscle injuries. A precise, accurate, cost effective, sensitive and simple UV- Spectroscopic method has been developed for the determination of mesalamine in bulk and pharmaceutical dosage forms. The solubility of Mesalamine was determined in a variety of solvents ranging from non polar to polar. The drug was found more soluble in methanol and HCl. For the cost effective manner and since the drug is stable in HCl for long time than in methanol, (3hrs). So 1N HCl was selected as solvent. The mesalamine shows absorbance at 303 nm in 1 N HCl and it obeys Beer’s law in the concentration range of 5 – 25 μ/ml. With a correlation coefficient (r2 - 0.0993), the results of analysis were validated by recovery studies. The method was successfully feasible to pharmaceutical formulation, because no interference from the tablet exceipents were found. The proposed method was found to be simple accurate and reliable for routine quantification of mesalamine in bulk form and pharmaceutical dosage form.

Keywords: mesalamine, UV spectroscope, Tablets, Precision.


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