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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF METFORMIN HYDROCHLORIDE

Mohd. Junaid*, Zubair Alam and Deepak Kumar Kushawah

ABSTRACT

Sustained-release polymeric beads containing Ciprofloxacin Hydrochloride fabricated with sodium alginate and chitosan were prepared by the ionotropic gelation method. Model drug, ciprofloxacin hydrochloride was entrapped in sodium alginate and Gelucire in different ratios. Here, calcium chloride was used as a cross-linking agent. Microbeads of Ciprofloxacin hydrochloride were prepared with different concentrations of polymers and electrolytes. The microbeads were characterized in terms of drug-excipient compatibility study, particle size analysis, shape analysis, drug content, encapsulation efficiency and in vitro drug release study. Results signified the fact that microbeads formed had sufficient good surface and size to be utilized as a dosage form responsible for sustained release of drug from matrix through erosion.

Keywords: Sustained release, Microbeads, Sodium alginate, chitosan, Gelucire, Ionotropic Gelation, Ciprofloxacin HCl.


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