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K. Venkata Gopaiah* and G. S. N. Koteswara Rao


Transdermal route offers several potential advantages over conventional routes. These advantages includes avoidance of first pass metabolism, predictable and extended duration of action, minimizing undesirable side effects, utility of short half-life drugs, improving physiological and pharmacological response, avoiding the fluctuation in the blood levels, and most important it provides patient convenience. But one of the major problems for efficient drug delivery is low penetration rate. Gel system showed topical delivery with higher transdermal flux and higher skin deposition and became an attractive option as it has several desirable advantages. Prepared is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin. To confirm the presence of vesicular structure, formulations were visualized under microscope at different magnified fields, which showed presence of lipid bilayer as well as spherical structure of vesicles. Using the same microscopic method and special software ―particle size analysis‖, size of vesicle was determined for sonicated. Vesicular size was found to be in the range of 0 – 5.483 μm. Vesicular size was reduced up to 3 folds by sonication in the evaluation. After confirmation regarding existence of vesicles and their size, drug entrapped by vesicular system was evaluated by ultra-centrifugation. Which showed effective sub dermal deposition and indicated better sub dermal action. The present study is related to the preparation of the transdermal gel for the treatment of inflammation by using the extracts of vitex negundo by the study it can be concluded that prepared gel is promising route of drug administration. Even though the TDDS faces the problem of drug permeation because of the rigid stratum corneum, it can be overcome by the use of penetration enhancers such as ethanol. The size of the Gel can be reduced by sonication

Keywords: thereby improving the skin permeation properties of gel. By encapsulating gel the frequency of dosing can be reduced as gel cause the delivery of drug for almost 10hrs.

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