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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
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  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
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Abstract

RECENT ADVANCES OF SOLID LIPID NANOPARTICLES: A REVIEW

U. Sahul Hameed Niyaz* and K. Elango

ABSTRACT

Most of the active pharmaceutical ingredients (APIs) under development are poorly water soluble and have poor bioavailability. Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The main advantage is that they are prepared with physiologically well-tolerated lipids. Solid Lipid Nanoparticles (SLNs) as novel lipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems of polymeric nanoparticles. By putting forward physiological safe lipids in place of polymers to prepare lipid nanoparticles, a novel formulation technique came into light. An approach undertaken here is to focus on various production methods for preparation of SLNs, wide pharmaceutical applications of SLNs in drug delivery are explored.

Keywords: Solid lipid nanoparticles; Colloidal delivery system; Oral Bioavilability; Water Insoluble Drugs; Preparation; Characterisation.


[Full Text Article]

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