Abstract

EVALUATION OF ANTI-HISTAMINE POTENTIAL OF SIDDHA FORMULATION VASANTHA KUSMAKARAM TABLET USING ISOLATED CHICK ILEUM PREPARATION

J. Nisha*, N. J. Muthu Kumar, S. Visweswaran, N. Anbu and V. Banumathi

ABSTRACT

Acute upper respiratory infections, including common cold, is one of the most prevalent infectious diseases in humans. Histamine a known autacoid play tremendous role in emphasizing the symptoms associated with allergy and cold which mainly mediated the inflammation, hyper secretion, dry cough etc. For the management of common cold and cough, antihistamines are used for their anticholinergic effects (i.e., drying up secretions), but in some patients, these anticholinergic effects can manifest as tachycardia, agitation and blurry vision. Typically, antihistamines are considered CNS depressants, causing drowsiness. In young children, however, a paradoxical effect, usually excitability, can be observed. Hence it is need of the hour to explore medicine from alternate source that has rich anti histamine potential and with less sedation. In recent years; traditional therapies have gained in popularity for medical and economic reasons, in both developing and industrialized countries. Siddha system of medicine follows traditional healing physiology which was derived by ancient siddha physician called siddhars who are the pioneers in identification of drugs and elucidated the pharmacology of each component. Siddha medicine also works behind the synergy of componential formulation one such medicine is Vasantha Kusmakaram tablet (VKT)which has twelve versatile ingredients which has tendency to synergies the action of each other in treating allergy and cold related symptoms. The main aim of the present investigation is to evaluate the anti-histamine potential of siddha formulation VKT using isolated chick ileum preparation. The results obtained from the present research have shown that treatment with VKT has significant reduction in height of the response induced by histamine in chick ileum preparation. Hence it was concluded that the formulation VKT has possess significant anti-histamine property and these pharmacological action may be possess by some of the bio active components which may be responsible for this property.

Keywords: Allergy, Common cold, Histamine, Siddha system, Vasantha Kusmakaram, Anti-histamine.