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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF SOME NEW PYRROLIDINE DERIVATIVES

*Abdul-Wahhab J. Al-Hamdany and Sevgi S. Arslan

ABSTRACT

2-naphthyl chalcones where prepared by using Claisen-Schmidt condensation. In addition, Schiff bases were produced by condensation of benzyl amine with substituted benzaldehyde, adding the latter to the chalcones by 1,3-anionic cyclo addition to the double bond of chalcones afforded the corresponding heterocycles pyrrolidines (1-24). Spectral data and some physical properties were used to support the structure of the new products. The proposed reaction mechanism was investigated using (H.F) and steric energy (S.E) calculation the antibacterial activity for pyrrolidines had been tested through it’s effects on two kinds of bacteria.

Keywords: 1,3-anionic cycloaddition, 2-naphthyl chalcones, Schiff’s Bases, pyrrolidines, antibacterial activity.


[Full Text Article]

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