TRANSFERSOME: A RECENT AND NOVEL APPROACHES IN TRANSDERMAL DRUG DELIVERY SYSTEM
*Himanshu G. Agrawal, Anil G. Raval, Dr. Yogesh K. Patel and Kajal Prajapati
ABSTRACT
Drug Delivery through Transdermal route represents a most convenient and novel approach. Transfersomes were found to be more effective as they render controlled release of drug due to depot formation in skin and were more effective. Transfersomes are applied to the skin and permeate through the stratum corneum lipid lamellar regions as a result of the hydration and osmotic force in the skin. Transfersomes have been widely used as a novel carrier for transdermal drug delivery. The Transfersomes can be evaluated by in vitro for vesicle shape and size, entrapment efficiency; degree of deformability, number of vesicles per cubic mm. Transfersomes enhances the penetration of most of the low as well as high molecular weight drugs. When tested in artificial
systems transfersomes can pass through even very small pores (100 nm) which are 1500 times smaller. The use of transfersomes carrier results in delivery of high concentration of active agents through the skin, regulated by system composition and their physical characteristics. Thus, this novel technique has got a potential for overcoming current problems faced by the conventional techniques.
Keywords: Transfersomes, Transdermal Drug Delivery System.
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