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  • FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

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Neha Chauhan* and Deepti M. Sati


Background: Aspirin belongs to Non Steroidal Anti- inflammatory Drugs (NSAID) which is one the most commonly prescribed class of drug in order to alleviate pain fever and inflammation. Its pKa being 3.5 and physiochemical properties facilitate its absorption in the acidic media of stomach. But gastric irritation and ulcer causing property is the major undesirable characteristic. Delayed release tablet can be commercially as well as patient compliant option of the gastric irritant aspirin tablets. Study In order to resolve this issue the objective was to optimize a delayed release formulation by coating the core tablet with acrylic based polymers and compare their release, stability and manufacturability. Although different enteric coating polymers are available like polyvinyl acetate pthalate, cellulose acetate phthalate, hydroxyl propyl methyl cellulose (HPMC), but acrylic polymers were chosen for this study because of their better stability. Study involved drug excipient screening, core tablet formulation, screening enteric coating polymers for desired release profile. Drug excipient compatibility study was done first. Evaluation of granular aspirin was performed. Core tablets were then formulated and coated with Kollicoat MAE100P and Eudragit L100.Stability studies for one month was also performed. Result & Conclusion: The coating with Kollicoat MAE100P provided the better dissolution and free salicylic acid profiles as compared to coating with Eudragit L100. Thus coating of delayed release tablet with Kollicaoat MAE100P found to be more stable and fulfilled the objective.

Keywords: Delayed release, Stability study, NSAID, Acrylates.

[Full Text Article]

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