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*Rochishna Moka, P. Shiva Prasad, Sai Kiran Baskarlu and Charuna Sri


Transferosome formulations were prepared by thin film hydration technique and were incorporated into 2% carbapol gel. The Formulation PT3 containing Lecithin: Tween-80 in ratio 85:15(%w/w) has higher entrapment efficiency and maximum drug release. In-vitro skin permeation study studies showed that, transferosome gels were found to increase the skin permeation and deposition showing a sustain effect. Stability studies performed for optimized transferosome gel formulations indicates that prepared transfersomes have more stability at freezing temperature than that of room temperature. Based on the above data, it was confirmed that prepared Piroxicam transferosome gel (PT3) can be considered as one of the promising approach to reduce the dosing frequency and to maintain drug concentration at the desired site for longer time. Finally, it can be concluded from the results of present study that Transferosomes gel improve the transdermal delivery, prolong the release, and improve the site specificity of the drug Piroxicam. Transferosomes creates a new opportunity for the well-controlled transdermal delivery of a number of drugs that have a problem of administration by other routes.

Keywords: Transferosome, Drug - Piroxicam, Phosphate Buffer, Transferosome gel, Lecithin, Phospholipid – Soya Lecithin, Edge Activator – Span 80, Tween 80, Volatile Solvents – Methanol, Chloroform, Gelling Agent - Carbopol 934.

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