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*R. Naga Ravali


Papaverine an alkaloid isolated from opium is a potent, specific inhibitor of PDE-10A. PDE-10A is almost exclusively expressed in the striatum and its inhibition results in increase in cAMP and cGMP, which is a novel therapeutic avenue in the discovery of antipsychotics. Search of novel targets for insulin secretion lead to recent discovery of the high expression of PDE-10A in pancreatic islets. Hence the present study was designed to evaluate the anti-psychotic and anti-diabetic activity of papaverine in high fat diet & apomorphine induced psychosis associated diabetes mellitus in SD rats. Male Sprague Dawley rats (130-150gm) were divided into four groups with six animals each. The control group animals were fed with standard chow diet whereas the negative control group and the two treatment groups were fed with high fat high sucrose diet(HFHSD) for a period of 6weeks along with weekly administration of apomorphine(1mg/kg,s.c). Papaverine treatment was started after three weeks i.e., after confirmation of glucose intolerance by performing oral glucose tolerance test. The treatment was continued for a period of three weeks. During the study behavioural parameters were estimated weekly once and at the end of the study the biochemical parameters were estimated.

Keywords: Papaverine, Psychosis, Diabetes mellitus, Insulin Resistance, high-fat diet, Apomorphine.

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