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  • WJPPS OCTOBER ISSUE PUBLISHED
  • OCTOBER 2018 Issue has been successfully launched on 1 October 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF IRBESARTAN

Priti P. Nikam*, Prashant S. Malpure, Yashpal M. More, Shital S. Patil

ABSTRACT

The aim of present investigation was formulation and evaluation of mucoadhesive buccal tablet of Irbesartan to study the effect of different polymers on release profile of drug for prolonged release. In this study mucoadhesive buccal tablet were prepared by direct compression method. Various rheological characteristics of the powder bed like bulk density, compressibility index, and angle of repose were evaluated and studied. Mucoadhesive buccal tablets were compressed on a 8 station mini press using 8 mm flat faced punches and were all assessed for weight variation, hardness, thickness, percent swelling index, mucoadhesive strength and in vitro release of the drug by using USP TDT 08L dissolution testing apparatus method II using a paddle at 50 rpm. Data was optimized by using 32 full factorial design by using software named as design expert and with the help of kinetic study. The stability studies showed that there is no decrease in the drug content of all formulations for the period of 2months.

Keywords: Buccal tablet, Irbesartan, Xanthan gum, Carbopol 934.


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