Abstract

SUSTAINED RELEASE MATRIX TABLET: A REVIEW

Kumar Sunil*, Mahajan Tejasavi, Suxam, Sohal Tania, Prashar Sonica, Malpotra Sohit, Bhandari Neeraj

ABSTRACT

Sustained release matrix tablet is formulated mainly by wet granulation or direct compression method or by dispersion of solid particle within solid particle within a porous matrix formed by using different polymers like Polymethyl methacrylate (PMMA), Polyglycolic acid, HPMC etc. The matrix controls the release rate of drug. retardants like HPMC can aid in sustained release and thus they form core excipient of the formulation. The method involves the direct compression of blend of drug, retardant material and additives to formulate a tablet in which the drug is embedded in a matrix core of the retardant, alternatively granulation can be carried out prior to compression. The matrices used may be of hydrophilic, hydrophobic, mineral, or biodegradable types. The drug release rate can be studied by in-ugs that have been formulated as sustained release matrix tablets are Ambroxol HCl, Nateglinide etc. Thus, sustained release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be of great help to treat chronic diseases.

Keywords: Polymethyl methacrylate (PMMA), Polyglycolic acid, HPMC etc.