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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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Abstract

ACUTE TOXICITY TEST OF THE COMBINED EXTRACT OF GAMBIR AND SECANG ON RATS

Sri Ningsih*

ABSTRACT

The combined extract of gambir (Uncaria gambir (Hunter) Roxb.) and secang (Caesalpinia sappan L.) (formula) had been proven to demonstrate lowering uric acid activity in vivo. This study was aimed to evaluate acute toxicity of this combined extract on rats. The test was carried out based on The Guideline issued by The Indonesian National Agency of Drugs and Foods Controls (Badan POM). For this purpose, 30 females and 30 males Sprague dawley strain rats were divided into 6 groups, each group consisted of 5 pairs of sex, namely 5 treatment groups and normal group. Samples suspended in water solution 0.5% CMC were gavaged once per orally (p.o.) and then these animals were assessed for clinical signs, body weight and number of mortality for 14-day period. The LD50 (lethal dose-50) value was determined using a linier equation of Microsoft Excel program. The results showed that the formula had LD50 value more than 15 mg/kg body weight (b.w.) without some toxic symptoms and the body weight changes of each group were not altered significantly. It may be concluded that formula was in the practically non-toxic category without any serious toxic symptoms.

Keywords: Acute toxicity test, Gambir (Uncaria gambir (Hunter) Roxb.), Secang (Caesalpinia sappan L.), Rat, LD50 value.


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