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Milena Theodoro, Daniele Cardoso dos Santos, Gabriel Teixeira Cagnin, Fabíola Garcia Praça and Wanessa Silva Garcia Medina*


Computed tomography (CT) imaging has rapidly become a commonplace diagnostic tool due to its utility in a wide range of diseases. To prospectively evaluate the incidence of reactions after exposure to Non-Ionic Contrast media (NICM), and to identify potential risk factors, with a focus on fasting duration for solid food and fluids, separately. Methods: From July to October 2017, 229 patients (117 men, 112 women; median age, 53.2 years; range, 04-90 years) undergoing ICM-enhanced CT were included in this study. Reactions after exposure to ICM exposure were assessed on a 3-point scale (mild, moderate, severe). Patients’ characteristics and the fasting duration were evaluated to identify risk factors using logistic regression analysis. Results: Of the 229 patients, 8 experienced hypersensibility reaction, no patients experienced vomiting. Multi-variate regression analysis revealed that a history of drug hypersensitivity (3.49%) was independent risk factors for nausea. Of the patients who presented hypersensitivity reactions, 12.5% were diabetic, 12.5% had asthma, 50% had systemic arterial hypertension, 50% had dyslipidemia, 0% had renal disease, 25% had no associated alterations (asthma, hypertension, diabetes, dyslipidemia, renal diseases. Conclusions: The adverse reactions to ICM agents were consisting in predictors analyzers like an allergic history to contrast agents, diabetic, asthma, systemic arterial hypertension, dyslipidemia, renal disease and urticaria, history of the previous allergy to drugs other than contrast agents. ICM Hypersensitive reactions occurred in 1.31% of patients. Our results showed that clinical decision based on patient clinical records resulted in a decrease of several immediate reactions incidence.

Keywords: Hypersensitivity reaction, iodinated contrast media, non-ionic contrast media, case report, clinical history.

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