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Syed Nisar Hussain Shah, Nida Javed*, Hina Javed, Niaz Hussain, Muhammad Yusuf, Sahima Alia and Mahtab Ahmad Khan


This study was aimed to formulate Linseed oil loaded Emulsion (o/w) based gels, by using various concentrations of rose oil and lemon oil as penetration enhancers for transdermal drug delivery. By using response surface methodology (RSM), different thirteen Linseed oil emulgels were formulated and optimized. All formulations were evaluated for stability studies, physico-chemical characteristics, spreadability, skin protection factor, thermal analysis, FT-IR and antimicrobial activity. In vitro drug release study was performed in cellophane membrane through dissolution apparatus (at 37ÂșC with 100rpm) for 24 hours in release medium at pH 6.8. The results were then statistically analyzed. Among all emulgel formulations, EG6 has shown maximum 96.69% Linseed oil release at higher concentration of Lemon oil with decreased concentration of Rose oil. Analysis of variance (ANOVA) was conducted to evaluate the results exhibited independent variables have remarkable effects (p < 0.05) on dependent variables. Multiple linear regression analysis (MLRA) was used to compare the results among different formulations of Linseed oil emulgel. Contour plots and 3D surface plots were also constructed to express the response between independent and dependent variables. All formulations have followed korsemeyer-peppas kinetic model. The optimized formulation having skin protection factor 19 has shown 85% antimicrobial activity, considered suitable for skin care. In summary, combination of penetration enhancers (rose oil and lemon oil) in Linseed oil emulgel can be successfully utilized for transdermal controlled drug delivery. Optimized emulgel has good permeability, prolonged residence time on skin surface and sufficient SPF, proved its strong anti-microbial activity in case of acne vulgaris and other skin problems.

Keywords: Linseed oil, Emulgel, Response surface methodology, SPF, Antimicrobial activity, Drug release kinetics.

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