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  • WJPPS OCTOBER ISSUE PUBLISHED
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Abstract

ASSESSMENT OF THE EFFECTS OF AN AQUEOUS TRUNK BARK EXTRACT OF PARKIA BIGLOBOSA (MIMOSACEAE) ON BLOOD SUGAR LEVELS IN RATS

Kassi Yomalan, Toto Kouamé Noël, Nanti Gooré Guy Charles Golé, Nene Bi Semi Anthelme* and Traoré Flavien

ABSTRACT

The aim of this study is to contribute to the enhancement of the traditional African pharmacopoeia, in view of the establishment of improved traditional medicines. A phytochemical screening and a toxicological study according to the guidelines and the recommendation 423 of the Organization for Economic Co-operation and Development (OECD) as well as Pharmacological tests of the aqueous extract of Parkia biglobosa (EAqPB) on blood glucose were performed. All tests substances have been administrated orally. Qualitative phytochemical tests carried out with the aqueous bark trunk extract of Parkia biglibosa (Mimosaceae) made it possible to highlight the presence of sterols and polyterpenes, alkaloids, polyphenols, catechin and gallic tannins, flavonoids and saponosides. The acute toxicity study of this extract in mice at doses of 2000 and 5000 mg/kg bw, did not cause any death. The effects of aqueous extract of Parkia biglibosa on blood glucose levels in normoglycemic rats showed good hypoglycemic activity at a dose of 1000 mg/kg bw, with a 17.37% reduction of glycemia. After glucose overload, EAqPB exhibited better antihyperglycemic activity in pretreated rats in contrast to glibenclamide, with a 32% reduction percentage compared to the control. EAqPB has hypoglycemic and antihyperglycemic properties that are probably related to the presence of alkaloids, tannins and flavonoids. These compounds, generally recognized for their hypoglycemic and antihyperglycaemic effects, give this extract properties similar to those of certain insulin secretors. These results are therefore favorable for its exploitation for the treatment of diabetes in traditional medicine and provide a scientific basis for its use.

Keywords: Parkia biglobosa, Toxicology, Hypoglycemic et Anti-hyperglycemic.


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