WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION OF WATER-IN-OIL MICROEMULSION CONTAINING VITAMIN E FOR TOPICAL APPLICATION

Tuane Nardacchione Garbin, Fabíola Garcia Praca, Jessica Messias da Silva, Maria Vitoria Lopes Badra Bentley and Wanessa Silva Garcia Medina*

ABSTRACT

Vitamin E is an antioxidant agent with low aqueous solubility and bioavailability which has been used to protects the skin from atopic dermatitis and various deleterious effects due to solar radiation by acting as a free-radical scavenger. The aim of the present study was to formulate, to characterize and in vitro evaluate the microemulsion containing vitamin E at 0.1% for topical skin application. In order to design suitable microemulsion system, appropriate amounts of isopropyl myristate, tween 80, propylene glycol and water able to encapsulating high vitamin E amount were earlier defined by our research group and herein characterized. Physicochemical properties such as particles size, polydispersity index, zeta potential and encapsulation efficiency were measured. The particles size, polydispersity index, zeta potential was obtained by dynamic light scattering method and the analysis indicated an average of particles size 250 nm, a low PDI index and negative zeta potential. In this work, the investigated vitamin E-loaded microemulsion and unloaded microemulsion (control) were unable to induce cell cytotoxicity in the concentration range below 0.75mg/mL of vitamin E after 24h cell exposure.

Keywords: .


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More