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  • WJPPS OCTOBER ISSUE PUBLISHED
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Abstract

FORMULATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION OF WATER-IN-OIL MICROEMULSION CONTAINING VITAMIN E FOR TOPICAL APPLICATION

Tuane Nardacchione Garbin, Fabíola Garcia Praca, Jessica Messias da Silva, Maria Vitoria Lopes Badra Bentley and Wanessa Silva Garcia Medina*

ABSTRACT

Vitamin E is an antioxidant agent with low aqueous solubility and bioavailability which has been used to protects the skin from atopic dermatitis and various deleterious effects due to solar radiation by acting as a free-radical scavenger. The aim of the present study was to formulate, to characterize and in vitro evaluate the microemulsion containing vitamin E at 0.1% for topical skin application. In order to design suitable microemulsion system, appropriate amounts of isopropyl myristate, tween 80, propylene glycol and water able to encapsulating high vitamin E amount were earlier defined by our research group and herein characterized. Physicochemical properties such as particles size, polydispersity index, zeta potential and encapsulation efficiency were measured. The particles size, polydispersity index, zeta potential was obtained by dynamic light scattering method and the analysis indicated an average of particles size 250 nm, a low PDI index and negative zeta potential. In this work, the investigated vitamin E-loaded microemulsion and unloaded microemulsion (control) were unable to induce cell cytotoxicity in the concentration range below 0.75mg/mL of vitamin E after 24h cell exposure.

Keywords: .


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