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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DEVLOPEMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SECNIDAZOLE GRANULES

Digambar Ashok Nagare*, Dr. Vipul P. Patel, Sima Gosavi and Tushar N. Deore

ABSTRACT

Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast RP-HPLC method for the analysis of Secnidazole Granules. A Waters HPLC system with Inertsil ODS-3V, C18, 150 mm, 5μm column is employed for the analysis using 0.01 M Potassium Dihydrogen Orthophosphate Buffer Solution, Acetonitrile And Methanol in the ratio of (70:25:5 v/v) as mobile phase. Signal from Secnidazole is detected at 228 nm by UV Spectrophotometer. The proposed method is fully validated and found to be linear over a workable drug concentration, accurate, precise and robust. This fast and inexpensive method and also this method is HPLC Equivalent to UPLC. It is suitable for research laboratories as well as for quality control analysis in pharmaceutical industries.

Keywords: Secnidazole, RP-HPLC, Waters system , validation etc.


[Full Text Article]

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