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Chavda Pooja C.* and Atanu Kumar Behera


Malaria has been described since ancient times as seasonal periodic fever. In humans, malaria is caused by four distinct species of parasites: Plasmodium vivax, Plasmodium falciparum, Plasmodium malariae and Plasmodium ovale. Existing treatments for malaria include a limited number of clinically effective antimalarial agents. World Health Organization guidelines for the treatment of uncomplicated falciparum malaria recommend the use of this Artemisinin-based combination therapy. Artemether is indicated for the treatment of P. falciparum malaria cases resistant to both Chloroquine and sulphadoxine, pyrimethamine combination. Artemether act as blood schizontocides. Artemether is a Sesquiterpine lactone derived from Artemisinin. Artemisinin is a compound derived from the sweet wormwood plant and has been used for centuries in traditional Chinese medicine to treat fever. Artemether is absorbed fairly rapidly with peak plasma concentrations reached about 2 hours after dosing. Artemether is poorly soluble in water. So current study was carried out for the determination of solubility of artemether in different phosphate buffer solution and also carried out study of standard calibration curve, melting point, FTIR and micromeritics property of artemether in preformulation study of drug. Results shows that in PH dependent solubility studies of Artemether, solubility was low at PH 6.8 and water and high at PH 4.5 and ethanol.

Keywords: Artemether, solubility, antimalarial agent.

[Full Text Article]

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