Photo Gallery

Login

Search

News & Updation

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

PREFORMULATION AND SOLUBILITY STUDY OF ARTEMETHER IN DIFFERENT PHOSPHATE BUFFER SOLUTION.

Chavda Pooja C.* and Atanu Kumar Behera

ABSTRACT

Malaria has been described since ancient times as seasonal periodic fever. In humans, malaria is caused by four distinct species of parasites: Plasmodium vivax, Plasmodium falciparum, Plasmodium malariae and Plasmodium ovale. Existing treatments for malaria include a limited number of clinically effective antimalarial agents. World Health Organization guidelines for the treatment of uncomplicated falciparum malaria recommend the use of this Artemisinin-based combination therapy. Artemether is indicated for the treatment of P. falciparum malaria cases resistant to both Chloroquine and sulphadoxine, pyrimethamine combination. Artemether act as blood schizontocides. Artemether is a Sesquiterpine lactone derived from Artemisinin. Artemisinin is a compound derived from the sweet wormwood plant and has been used for centuries in traditional Chinese medicine to treat fever. Artemether is absorbed fairly rapidly with peak plasma concentrations reached about 2 hours after dosing. Artemether is poorly soluble in water. So current study was carried out for the determination of solubility of artemether in different phosphate buffer solution and also carried out study of standard calibration curve, melting point, FTIR and micromeritics property of artemether in preformulation study of drug. Results shows that in PH dependent solubility studies of Artemether, solubility was low at PH 6.8 and water and high at PH 4.5 and ethanol.

Keywords: Artemether, solubility, antimalarial agent.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More