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Sagar S. Kolhe* and M. P. Dabhade


The aim of present work is the formulation and evaluation of sustained release bilayer tablets of Losartan Potassium. In this formulation loading dosage was incorporated in the immediate release layer so that the minimum effective concentration may be attained within a short period of time after this the maintenance dosage level will be taken over by the drug release from the second layer of bilayer tablets. The tablets were prepared by direct compression method by using superdisintegrants sodium starch glycolate(SSG) for immediate release layer & mucoadhesive materials such as hydroxypropyl methylcellulose(HPMC-K4M) and carbopol 940-P for sustained release layer which could release the drug up to 30 hours in predetermined rate. All the formulations were evaluated for post-compression parameters like hardness, thickness, friability, dug content uniformity, dissolution test and disintegration test. Formulation ME5 was considered to be the optimized formulation which showed the best drug release profile up to 30 hours and fulfilled the many requirements reduced dosing frequency, increase the bioavailability and provide better patient compliance. The results of FTIR and DSC analysis showed that there was no physical and chemical interaction between drug and other excipients. The stability studies of optimized formulation ME5 at 400C/75%RH for 3 months did not show any variation in the tasted parameter and release.

Keywords: Losartan Potassium, Bilayer tablets, Formulation, Evaluation.

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