Photo Gallery

Login

Search

News & Updation

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF LOSARTAN POTASSIUM

Sagar S. Kolhe* and M. P. Dabhade

ABSTRACT

The aim of present work is the formulation and evaluation of sustained release bilayer tablets of Losartan Potassium. In this formulation loading dosage was incorporated in the immediate release layer so that the minimum effective concentration may be attained within a short period of time after this the maintenance dosage level will be taken over by the drug release from the second layer of bilayer tablets. The tablets were prepared by direct compression method by using superdisintegrants sodium starch glycolate(SSG) for immediate release layer & mucoadhesive materials such as hydroxypropyl methylcellulose(HPMC-K4M) and carbopol 940-P for sustained release layer which could release the drug up to 30 hours in predetermined rate. All the formulations were evaluated for post-compression parameters like hardness, thickness, friability, dug content uniformity, dissolution test and disintegration test. Formulation ME5 was considered to be the optimized formulation which showed the best drug release profile up to 30 hours and fulfilled the many requirements reduced dosing frequency, increase the bioavailability and provide better patient compliance. The results of FTIR and DSC analysis showed that there was no physical and chemical interaction between drug and other excipients. The stability studies of optimized formulation ME5 at 400C/75%RH for 3 months did not show any variation in the tasted parameter and release.

Keywords: Losartan Potassium, Bilayer tablets, Formulation, Evaluation.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More