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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

DESIGN, MOLECULAR DOCKING, SYNTHESIS, & ANTI-CANCER EVALUATION OF NOVEL XANTHENE DERIVATIVES

Dr. Sujit Kumar Mohanty*, Anuradha Khuntia, B. Sandhyarani, Yashaswini, B. Likitha, C. I. Muzammil, Sneha, Harshitha, P. Samuel Shine

ABSTRACT

A series of seven new Xanthene derivatives were synthesized by reacting appropriate amines with ester of fluorescein. Different derivatives were synthesized using unique techniques. Purity of synthesized compound was checked by TLC and structures were elucidated by their IR, 1H NMR and Mass data. The synthesized compounds were screened for anti-cancer activities using Hela cell line (Cervical Cancer). All the products showed good binding scores (Insilco) with respective receptors. Moreover, Compound SDC, SAN & SHH, showed potential in-vitro cytotoxicity activity when compared to standard drugs.

Keywords: Xanthene derivatives, Hela cell line, Insilco, in-vitro cytotoxicity.


[Full Text Article]

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