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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG RIVAROXABAN BY SOLID DISPERSION TECHNIQUE

Bidkar S. J.*, Gaykar Akshay S.* and Dr. G. Y. Dama

ABSTRACT

Solid dispersions in water soluble carriers have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of rivaroxaban leads to poor dissolution & hence variation in bioavailability. In present study solid dispersion using various carriers like mannitol & lactose in different ratios were prepared by solvent evaporation method. The prepared solid dispersions were characterized for drug content, asolubility & dissolution rate. The dissolution rate substantially improved for rivaroxaban from its solid dispersions compared with pure drug. Dissolution rate increased with increase in carrier content. The dissolution rate was increased 3 folds with solid dispersions containing 1:4 of drug: lactose. The granules of rivaroxaban solid dispersion containing 1:4 of drug: lactose ratio was prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, compressibility index & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies. We can conclude that all the parameters were within the acceptable limits.

Keywords: Solid dispersion, Rivaroxaban, Dissolution rate, Solvent evaporation, Solubility.


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