Photo Gallery

Login

Search

News & Updation

  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

FORMULATION AND IN VITRO EVALUATION OF BUCCAL TABLETS OF CHLORPROMAZINE HCL

Prof. Shital J. Bidkar, *Sadhana S. Ghule, Dr. Dama G. Y.

ABSTRACT

The aim of study was to prepare and characterize buccal tablets of Chlorpromazine HCl. using different Mucoadhesive polymers such as Sodium alginate, PVP K30 and HPMC K100M in combination. six formulations were prepared with varying concentrations of polymers using combination of two polymers in each formulation. Formulations F1 to F3 were composed of PVP K30 and HPMC K100M mixture in polymer mixture ratios of 1:2 to 2:1 where as formulations F4 to F6 were composed of PVP K30 and Sodium Alginate mixture in same polymers mixture ratios. The prepared tablets were evaluated for physicochemical parameters such as hardness, thickness uniformity, weight variation, surface pH, and moisture absorption studies. The prepared tablets were also evaluated for bioadhesive strength and in vitro drug release. In vitro bioadhesive strength and in vitro release studies showed that formulation F1 containing 1:2 ratio of polymers combination showed optimum bioadhesive and exhibited optimum drug release. The results indicate that the mucoadhesive buccal tablets of Chlorpromazine HCl. may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Chlorpromazine HCl. through buccal mucosa.

Keywords: Chlorpromazine HCl, buccal tablets, HPMC, control release, swelling index.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More