Abstract

PRE- SEPSIS BIOMARKER: HDL (HIGH DENSITY LIPOPROTEINS)

*Al-Zaidawi, Sejad, Al-hashimi, Ridha

ABSTRACT

Background: Delay in diagnosis and initiation of antibiotics treatment during sepsis have been shown to increase mortality. Biomarkers can play an important role in diagnosis and prognosis of sepsis. We aimed to evaluate the correlation between septicemia and high density lipoproteins (HDL) level in burned patients. Method: A prospective study conducted at Al-Sadr teaching hospital, Maysan, Iraq, during period from April to September 2013. Blood samples were collected from patient every other day to measure the level of HDL and triglycerides. Other blood samples were collected in blood culture tubes for culturing to verify septicemia. Results: Seventy five patients were admitted consecutively into burn unit, 35 of them (46%) developed septicemia. About 11 patients of the 35 patients are died. All died patients had HDL value (< 5 mg/dl) 1 or 2 days before death since our blood samples were collected every 2 days. Patients with high density lipoproteins (HDL) value < 15 mg/dl were with high risk of developing sepsis. Conclusion: There was a strong correlation between HDL level and septicemia in burned patient. HDL value is a good biomarker for sepsis, it decreases below normal level and continues to diminish and reach to immeasurable level at advance stage of septicemia. Word account (215) Tables (5) Figures (3)

Keywords: antibiotic, biomarkers, burns high density lipoproteins (HDL), septicemia, and triglycerides