SOLUBLE CD40 LIGAND (SCD40L)- A REVIEW
Nitin Tyagi*, Namrata Bhutani, Charanjeet Kaur, Anita Rani, Bhaskar Charana Kabi and Amita Yadav
ABSTRACT
Cancer cells can induce a variety of soluble factors, which have an immunosuppressive effect that helps tumor cells evade host immune responses. Emerging evidence suggests that myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs) play a critical role in generating these tumor-derived soluble factors.[1] In humans, MDSCs are commonly defined as cells that express the myeloid marker CD33 but lack expression of HLA-DR.[2] An endocrine loop between tumor and suppressor cells, bridged by tumor-derived soluble factors, such as TGF-β, IL-10, GM-CSF, and VEGF, can generate a potent immunoinhibitory effect on antitumor responses and promote survival and proliferation of cancer cells.[3,4] Thus, studying new tumor-derived soluble factors necessary for the generation of suppressor-cell populations, and then targeting these factors, could be an additional strategy for treating cancer patients with immunotherapy.
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