WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

A REVIEW ON EXTENDED RELEASE DRUG DELIVERY SYSTEM

Bidkar S. J.*, Jadhav Rahul G.* and Dr. G. Y. Dama

ABSTRACT

Recently, extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic. Early drug delivery systems (DDS) tended to give non-constant release rates, although this was still a large improvement over immediate release formulations. The ideal DDS should show a con- stant zero order release rate, as this has the potential to create constant plasma concentrations Many current oral extended release systems are of the matrix type, based on hydrophilic polymers. With these technologies, drug and excipients are mixed with polymers such as hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellu- lose (HPC), and then formed as a tablet by conven- tional compression. Release from these tablets takes place by a combination of physical phenomena. Water diffuses into the tablet, swells the polymer and dissolves the drug, whereupon the drug may diffuse out to be absorbed. If the drug diffuses out faster than the polymer dissolves, the release rate declines with time.

Keywords: hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellu- lose (HPC).


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More