A REVIEW ON EXTENDED RELEASE DRUG DELIVERY SYSTEM
Bidkar S. J.*, Jadhav Rahul G.* and Dr. G. Y. Dama
ABSTRACT
Recently, extended release pharmaceutical products became a very useful tool in medical practice, offering a wide range of actual and perceived advantages to the patients. Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release is also providing promising way to decrease the side effect of drug by preventing the fluctuation of the therapeutic. Early drug delivery systems (DDS) tended to give non-constant release rates, although this was still a large improvement over immediate
release formulations. The ideal DDS should show a con- stant zero order release rate, as this has the potential to create constant plasma concentrations Many current oral extended release systems are of the matrix type, based on hydrophilic polymers. With these technologies, drug and excipients are mixed with polymers such as hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellu- lose (HPC), and then formed as a tablet by conven- tional compression. Release from these tablets takes place by a combination of physical phenomena. Water diffuses into the tablet, swells the polymer and dissolves the drug, whereupon the drug may diffuse out to be absorbed. If the drug diffuses out faster than the polymer dissolves, the release rate declines with time.
Keywords: hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellu- lose (HPC).
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