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Abstract

FREE RADICALS SCAVENGING PROFILES AND ANTIFUNGAL CAPACITY OF ETHYL ACETATE FRACTION (EAF) OF STEM BARK FROM BOSWELLI DALZIELII HUTCH (BURSERACEAE)

Dr. Konaté Kiessoun*, Ouattara Nabèrè, Metuor Dabiré Amana, Alain Souza and
Mamoudou H. Dicko

ABSTRACT

Background: The present study was designed to evaluate the in
vitroantioxidant and the antifungal activity of EAF of stem bark from
Boswelli dalzielii Hutch (Burseraceae) against Candida albicans,
Candida parapsilosis, Candida tropicalis and Candida krusei strains
and to determine its mode of action and synergistic effect when
combined with the synthetic antifungal nystatin. Methods: The
antioxidant activity of EAF of stem bark from Boswellidalzielii Hutch
has been evaluated using 1,1-diphenyl-2-picrylhydrazyl inhibitory
activity and chelation of iron (II) ions.The antifungal activity was
investigated using the microplate dilution method and the Fractional
Inhibitory Concentration Index (FICI) of EAF of stem bark was
evaluated. Results: EAF of stem bark exhibit maximum radical
scavenging activity. As for the antifungal activity, result varied according to microorganism. The results obtained in this antifungal activity were interesting and indicated a synergistic effect between of EAF of stem bark from Boswellidalzielii and the antifungal references such as Nystatin. The results of this study showed that of EAF of stem bark from Boswellidalzieliiin combination with antifungal reference (Nystatin) exhibited antimicrobial effects against candida strains tested. Conclusion: Therefore, this study shows a fungicidal effect on Candida species and a synergistic effect when combined with nystatin and the results supported the utilization of this Burseraceae in treatment of candida infections.

Keywords: Free radicals scavenging, Antifungal, Ethyl Acetate Fraction, stem bark, Boswellidalzielii Hutch.


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