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*Neelam Mallick, Fakhsheena Anjum, Huma Ali and Nusrat Bano


Introduction: Memory is very much influenced by elements such as, quality of sleep, Stress and food. There is an emergent proof to imply that citrus fruits with flavonoids and foods rich in flavonoids might exhibit reformative activity in such neuronal and memory enhancement, thereby impede the progression of disease condition. Citrus sinensis (sweet orange) and Citrus paradisi is widely known for its health-related benefits though it has been observed the growing use of dietary and herbal compounds are employed as treatment of anxiety and depression. Objective: The objective of this study was to describe the memory and learning properties of Citrus juices. Study Design: To evaluate the memory boosting effect of Citrus juices, Citrus sinensis and Citrus paradisi juice were used at three different doses alone and their two combinations in adult albino mice using Passive Avoidance response apparatus named Harvard Panlab controlled through LE2708 Programmer. Settings: To assess short or long-term memory of small animals Passive avoidance is used that is fear-motivated tests. Method: To assess the working memory of mice through passive avoidance by measuring latency to enter into the black compartment in two different sessions, that is, conditioning phase and Non-conditioning or test phase. Results: Animals showed highly significant increase at HCSD after 3 hr as compare to control latency time. There was highly significant increase in test latency time at MCPD observed after 3 hr and significant increase after 24 hr as compare to control latency time. There was significant increase at SPJ-1 and SPJ-2 observed after 3 hr in comparison with control latency time. Conclusion: It can be concluded that intake of fruit flavonoids results in Cognitive changes and most likely it involves morphological changes triggered by the direct actions of flavonoids on neuronal signalling.

Keywords: Learning, Citrus sinensis (sweet orange), Citrus paradisi.

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