Abstract

SERUM PREGNANCY-ASSOCIATED PLASMA PROTEIN AND MATERNAL SERUM INSULIN-LIKE GROWTH FACTOR-I LEVELS IN PREECLAMPSIA IN EGYPTIAN WOMEN

Amal K. Seleem, Abdel Aziz A. A., Hosam Abdelfatah, El-Gharib M. A., Faeza El-Dahtory and Eatimad A. Basha*

ABSTRACT

Background: Preeclampsia is a severe complication of human pregnancy that occurs in 3–5% of all pregnancies and may threaten maternal and fetal survival. Objective: To determine the frequency of the Serum pregnancy-associated plasma protein A and maternal serum insulin-like growth factor-I levels in preeclampsia at second trimester and to verify severity of preeclampsia would be associated with PAPP-A and IGF-I levels. Methods: Case-control study included 60women with Preeclampsia, and 30normotensive women as control. Three groups were chosen; preeclampsia group consisted of 30women, mild preeclampsia (MPE) group, 30 women, severe preeclampsia group (SPE) and control group 30 women. All groups were matched strictly for gestational age at second trimester. Maternal blood samples for PAPP-A and IGF-I were collected as soon as the patients at second trimester and compared. The IGF-I was measured with ELISA and The quantitative determination of PAPP-A in the maternal serum was performed with an Immulite / Immulite1000 device using solid phase, chemiluminescence immunometric sandwich method. Results: Mean ages of participants, weights and gestational week were similar. Mean PAPP-A and IGF-I levels were significantly lower in preeclampsia groupscompared to control group. However, PAPP-A and IGF-I levels were not different among mild preeclampsia and severe preeclampsia groups. Conclusion: PAPP-A and IGF-I levels at second trimester decrease in all preeclampsia, mild preeclampsia (MPE) group and severe preeclampsia group (SPE), and may be useful in predicting the risk of preeclampsia.

Keywords: PAPP-A, IGF-I, Preeclampsia, Egyptian Women.