Photo Gallery

Login

Search

News & Updation

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

SERUM PREGNANCY-ASSOCIATED PLASMA PROTEIN AND MATERNAL SERUM INSULIN-LIKE GROWTH FACTOR-I LEVELS IN PREECLAMPSIA IN EGYPTIAN WOMEN

Amal K. Seleem, Abdel Aziz A. A., Hosam Abdelfatah, El-Gharib M. A., Faeza El-Dahtory and Eatimad A. Basha*

ABSTRACT

Background: Preeclampsia is a severe complication of human pregnancy that occurs in 3–5% of all pregnancies and may threaten maternal and fetal survival. Objective: To determine the frequency of the Serum pregnancy-associated plasma protein A and maternal serum insulin-like growth factor-I levels in preeclampsia at second trimester and to verify severity of preeclampsia would be associated with PAPP-A and IGF-I levels. Methods: Case-control study included 60women with Preeclampsia, and 30normotensive women as control. Three groups were chosen; preeclampsia group consisted of 30women, mild preeclampsia (MPE) group, 30 women, severe preeclampsia group (SPE) and control group 30 women. All groups were matched strictly for gestational age at second trimester. Maternal blood samples for PAPP-A and IGF-I were collected as soon as the patients at second trimester and compared. The IGF-I was measured with ELISA and The quantitative determination of PAPP-A in the maternal serum was performed with an Immulite / Immulite1000 device using solid phase, chemiluminescence immunometric sandwich method. Results: Mean ages of participants, weights and gestational week were similar. Mean PAPP-A and IGF-I levels were significantly lower in preeclampsia groupscompared to control group. However, PAPP-A and IGF-I levels were not different among mild preeclampsia and severe preeclampsia groups. Conclusion: PAPP-A and IGF-I levels at second trimester decrease in all preeclampsia, mild preeclampsia (MPE) group and severe preeclampsia group (SPE), and may be useful in predicting the risk of preeclampsia.

Keywords: PAPP-A, IGF-I, Preeclampsia, Egyptian Women.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More