Photo Gallery

Login

Search

News & Updation

  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  

Abstract

EFFECT OF FRACTIONS OF BRIDELIA MICRANTHA ON INSULIN RESISTANCE AND LIPID PROFILES IN HIGH SALT-INDUCED INSULIN RESISTANT RATS AND IDENTIFICATION OF PHYTOCONSTITUENTS BY GC-MS

Ajao Folasade O* and Soladoye Ayodele O.

ABSTRACT

This present study investigates the effect of fractions of Bridelia micrantha leaves on insulin resistance and lipid profiles in high salt-induced insulin resistant rats and its identification of phytoconstituents by Gas chromatography-mass spectroscopy (GC-MS). Crude methanol leaf extract of Bridelia micrantha was fractionated using silica gel column chromatography to yield 48 fractions. Pooling together of fractions with similar thin layer chromatographic (TLC) mobility profile afforded four major fractions (Fr A – Fr D). Bioactivity of the fractions obtained was evaluated in insulin resistant Wistar rats. Female Wistar rats were given (p.o.) normal diet (CON), high-salt diet (8%) daily (HS), Fr A-Fr D (HS rats treated with 10mg/kg bw of fractions A-D). Insulin resistance (IR) was estimated using the homeostatic model of assessment (HOMA). Results showed that high salt diet led to significant increases in insulin resistance, plasma insulin, total cholesterol (TC), triglyceride (TG), TC/HDL-cholesterol, and decreased glucose tolerance. Fraction B was the most effective in attenuating insulin resistance and dyslipidaemia. Fraction B of methanol extracts of Bridelia micrantha yielded 18 different phytochemicals confirmed by GC-MS analysis, some of which are known to have antidiabetic properties. In conclusion, the present study report the use of fractions of Bridelia micrantha leaves in the attenuating insulin resistance and dyslipidaemia in rats fed high salt diet and also identified the presence of compounds that could be responsible for these actions.

Keywords: Bridelia micrantha, High salt, Insulin resistance, Dyslipidemia, GC-MS.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More