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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

PREPARATION AND CHARACTERIZATION OF CUBOSOMES, AS ADVANCED DRUG DELIVERY SYSTEM FOR LOW SOLUBILITY DRUGS

Mandana Tajmal* and D. Narasimha Reddy

ABSTRACT

The main aim of this work was to formulate and evaluate cubosome as nanoparticle to enhance the solubility of water insoluble/ lipophilic and partially soluble drugs by using suitable polymers such as monoolein and poloxamer 407. In this study ibuprofen was used as model drug because of its extensive use as analgesic and anti-pyretic in different types of dosage forms. Cubosome of ibuprofen was prepared in three different formulations. The nanoparticles were characterized by spectroscopic studies such as DSC, XRD and SEM. The prepared ibuprofen cubosome was formulated as oral gel by incorporation in HPMC in different concentration of 1.5% and 3%. The optimized gel was studied for diffusion profile and compared with the native ibuprofen gel. Result indicates that a low solubility drug like ibuprofen can be better solubilized as a cubosome.

Keywords: Cubosome, Ibuprofen, Monoolein, Poloxamer, HPMC.


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