PREPARATION AND CHARACTERIZATION OF CUBOSOMES, AS ADVANCED DRUG DELIVERY SYSTEM FOR LOW SOLUBILITY DRUGS
Mandana Tajmal* and D. Narasimha Reddy
ABSTRACT
The main aim of this work was to formulate and evaluate cubosome as nanoparticle to enhance the solubility of water insoluble/ lipophilic and partially soluble drugs by using suitable polymers such as monoolein and poloxamer 407. In this study ibuprofen was used as model drug because of its extensive use as analgesic and anti-pyretic in different types of dosage forms. Cubosome of ibuprofen was prepared in three different formulations. The nanoparticles were characterized by spectroscopic studies such as DSC, XRD and SEM. The prepared ibuprofen cubosome was formulated as oral gel by incorporation in HPMC in different concentration of 1.5% and 3%. The optimized gel was studied for diffusion profile and compared with the native ibuprofen gel. Result indicates that a low solubility drug like ibuprofen can be better solubilized as a cubosome.
Keywords: Cubosome, Ibuprofen, Monoolein, Poloxamer, HPMC.
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