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  • WJPPS NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2018 Issue has been successfully launched on 1 November 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

FORMULATION, OPTIMIZATION AND EVALUATION OF GLYCEROGELATIN INSITU FILM CONTAINING ETHANOLIC LEAF EXTRACT OF CALOTROPIS GIGANTEA

A. J. Chacko and Reshma Thampy*

ABSTRACT

The aim of the study was to design, optimize and evaluate transdermal glycerogelatin insitu film containing Calotropis gigantea leaves extract for the treatment of Arthritis. Skin is considered as an important route of administration for both local and systemic effects. Topical film forming systems are developing drug delivery system ment for topical application to the skin, which adhere to the body, forming a thin transparent elastic film which provide delivery of active ingredient to the body tissue. The formulation was optimized by mixture design (design expert software, version 11.03) with glycerin, gelatin, water as the factors and spreadability, elasticity, drying time, tensile strength as the responses. Calotropis gigantea having significant anti -inflammatory potential and its ethanolic extract was incorporated into the optimized formula of glycerogelatin insitu film. The optimized formula contained 1.5% of drug exract and showed a drug release of 79 % at 8th hour, and 96% in 24 hour time period.

Keywords: Arthritis, insitu film, Calotropis gigantea, Optimization, Mixture design.


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