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Abstract

EVALUTION OF ANTI-INFLAMMATORY ACTIVITY SCINDAPSUS OFFICINALIS FRUIT IN CARRAGEENAN-INDUCED PAW OEDEMA RATS

K. Ratna Kumari*, Dr. J. N. Suresh Kumar and K. Ashok

ABSTRACT

The plant Scindapsus officinalis (Roxb.) Schott fruits are widely used in many parts of India for the treatment of various diseases and ailments. It is one of the plants used in Indian system of medicine which belongs to family aracea. The plant is growing in tropical parts of India. The fruit of Scindapsus officinalis is known as Gajpeepal in ayurveda. Gajpeepal consists of dried, transversely cut pieces of mature female spadix of Scindapsus officinalis (Fam. Araceae). Material: Group I-Control, animals were treated with 10% Tween-80 p.o, Group II--Standard group, animals were treated with 10mg/kg Indomethacin, Group III-Animals were treated with 30mg/kg b wt. p.o of isolated piperine from Sindapsus officinalis fruits. Group IV- Animals were treated with 60mg/kg b wt. p.o of isolated piperine from Sindapsus officinalis fruit. Results & Discussion: Animals treated with standard drug like piperine (10mg/kg) produces highly significant paw edema volume when compared to control animals. Whereas, high dose of 400 mg/kg isolation of piperine from scindapsus officinalis fruit produces highly significant decreased paw edema volume which is similar to the response of Piperine treatment. When compared to control animals. In case of low dose 200 mg/kg isolation of piperine from scindapsus officinalis fruit produces significant decreased paw edema volume when compare to control animals.

Keywords: Scindapsus officinalis, Gajpeepal, anti inflammatory.


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