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Parul Raje* and Shikha Agrawal


Objective: The aim of the present investigation is to formulate & evaluate the solid lipid nanoparticles (SLN) based topical gel of ibuprofen for the treatment of mild to moderate pain, which would avoid the gastrointestinal-related toxicities associated with oral administration. Methods: Solid lipid nanoparticles were formulated by melt emulsification and solidification at low-temperature method using stearic acid & tween 80. Various batches of SLN were prepared using different concentrations of lipid and surfactant, then SLN were incorporated into carbopol gel base to form a gel. Results: All the Preformulation parameters of the drug were evaluated such as physical characterization, melting point, pH, identification by UV spectroscopy and FTIR analytical method, preparation of calibration curves, solubility. Then SLN were subjected to scanning electron microscopy, drug entrapment efficiency (EE), particle size determination. It has been observed that high lipid concentration containing formulation have higher entrapment as. Finally, the formulation of SLN based topical gel was subjected to further study such as physical appearance, pH, viscosity determined using a Brookfield and Spreadability. The In-Vitro drug release of all the formulated gel was evaluated using Modified Franz diffusion cell containing dialysis membrane and phosphate buffer having pH 7.4 in the receptor medium. The in-vitro release was carried out in comparison with a marketed gel (Ribufen® gel). Conclusion: The research work concluded that all the Ibuprofen loaded SLN based topical gel formulation containing carbopol was suitable for topical application and having good penetration power.

Keywords: SLN, Ibuprofen, carbopol, Topical Gel.

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