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Karishma Nikose*, A. S. Pratapwar, Deepak Joshi and Avinash V. Dhobale


The buccal region offers an attractive route of administration for systemic drug delivery. Glimepiride isa potent drug against Diabetes mellitus-II with a half life of 3-5 hours. Though Glimepiride has 100% oral absorption, due to high first pass metabolism its bioavailability is less. The recommended dosage is4 mg b.i.d leading to admistration of the drug twice a day. The present study is aimed to design sustained release mucoadhesivebuccal patch formulation of Glimepiride in order to by-pass GIT and release the drug for extended periods of time. Buccal patches were formulated using polymers Carbopol 934 P(CP 934 P), polyvinyl alcohol and Hydroxy Propyl Methyl Cellulose E 15 (HPMC E 15) in various proportions and combinations. The patches were prepared by solvent casting method. The designed patches were evaluated for thickness uniformity, folding endurance, weight uniformity, content uniformity, swelling behaviour, determination of mucoadhesive time and buccal mucosa sensitivity test. In vitro diffusion studies were conducted for 6 hours in phosphate buffer (pH 6.8) solution using dialysis membrane. Formulation containing maximum amount of swellable and hydrophilic polymer HPMC E 15 and CP 934 P, showed higher swelling index. This occurred due to more hydrophilic polymeric matrix composition which retarded the release of the drug. The diffusion followed zero order kinetic model (R2 = 0.9995).

Keywords: Glimepiride, Buccal, Carbopol, HPMC E 15, Diabetes.

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