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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE USING NATURAL GUMS AND SYNTHETIC POLYMERS

Palli Bhagyasri and Srinivasa Rao Baratam*

ABSTRACT

The aim of this work is to formulate a sustained release matrix tablets using natural gums and synthetic polymers as a matrix forming materials. Ranolazine was selected as a model drug. Due to the low biological half-life it requires frequent administration. Hence sustained or prolonged release dosage forms are formulated to reduce the dosing frequency thereby improving patient compliance. Main objective of the work is to formulate sustained or prolonged dosage form by adopting direct granulation method using Carbopol 974P, guar gum and Eudragit RS 100 as a retarding material at different concentrations. All the formulations are evaluated for hardness, friability, thickness, weight uniformity, content uniformity and in vitro dissolution studies and followed by stability and kinetics study for the best formulation among them.

Keywords: Ranolazine, Carbopol 974P, guar gum, Eudragit RS 100, in vitro dissolution and sustained release tablets.


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