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Abstract

ANTI-INFLAMMATORY ACTIVITY OF SYZYGIUM CERASOIDEUM LEAF EXTRACT BY CARRAGEENAN INDUCED PAW OEDEMA IN ALBINO RATS

Shaik Sadik*, Geetha K. M., Sridhara Murthy N. B. and Vasia

ABSTRACT

Syzygium cerasoideum (Myrtaceae) is an Indian medical plant used traditionally for its anti rheumatic, hypoglycemia and rubifacient activities. It is also used in dysentery and the root infusion is applied over painful joints. It is used as pain reliever by Ayurveda, Siddha and Unani practitioners, but lacks scientific validation. The Anti-inflammatory property of the aqueous (AQSC) and methanolic extract (MESC) of Syzygium cerasoideum was evaluated using carrageenan induced paw oedema model in wistar albino rats. The AQSC and MESC leaf extracts at 200 and 400 mg/kg showed significantly (P<0.001) at 3rd and 4th h after administration. MESC at 400 mg/kg showed significant anti-inflammatory activity at 4th h, where it caused 55.95% inhibition. The Anti-inflammatory effect of both the extracts at 400 mg/kg b.w.p.o are comparable to that of standard drug Diclofenac (5 mg/kg b.w.p.o). The results of present study demonstrate that aqueous and the methanolic extracts of leaves of Syzygium cerasoideum possess significant anti-inflammatory potential and explicate justification of the use of this plant in the treatment of inflammatory disease conditions.

Keywords: Syzygium Cerasoideum, Diclofenac, Carrageenan.


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