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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

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Abstract

FORMULATION AND EVALUATION OF VALSARTAN FAST DISSOLVING TABLETS

Sujitha Bajjuri*, G. Sudershan Goud, Mazrina Tazeen, Mohd. Muqeem Pasha, Sarah Kazi, Tazmeena and Md. Imtiyaz Uddin

ABSTRACT

The aim of the study was to formulate and evaluate orally disintegrating tablet of Valsartan. Direct compression method was used to formulate orally disintegrating tablet of Valsartan by employing sodium starch glycolate and crospovidone as superdisintegrants, microcrystalline cellulose as filler and magnesium stearate (lubricant), Talc. The powder blends were evaluated for flow property and compressed into tablets by direct compression technique. These prepared FDTs were evaluated for physicochemical properties and parameters such as average weight, thickness, weight variation, hardness, friability, disintegration time, drug content and dissolution profile. Dissolution and drug content tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. Effect of superdisintegrant on disintegration behaviour of tablet and effect direct compression method on drug release profile were studied using artificial saliva. Among all the formulations, F3 has taken least time for disintegration and also release profiles of F3 were found to be satisfactory comparative to other formulations. So F3 Formulation was found to be the best for the preparation of valsartan orally disintegrating tablets as it has exhibited faster disintegration and best dissolution profile when compared to other formulations.

Keywords: Valsartan, superdisintegrants, direct compression technique, in vitro drug release studies.


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