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  • WJPPS AUGUST ISSUE PUBLISHED
  • AUGUST 2018 Issue has been successfully launched on 1 August 2018

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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILM OF PROPRANOLOL HYDROCHLORIDE

Patil Jyoti N.*, Rajdeo Archana V., Patil Samruddhi S. and Gavitre S. B.

ABSTRACT

The aim of the current study is to prepare fast dissolving film of propranolol hydrochloride to provide rapid onset of action and incrse bioavailability of drug. Propranolol is a nonselective beta adrenergic blocker and is almost completely absorbed following oral administration. Fast dissolving film were prepared by solvent casting method using hydroxyl propyl methyl cellulose (HPMC E15) and natural polymers like maltodextrin. Propranolol is bitter in taste so asprtame is used as sweetening agent in combination with menthol cooling effect of which also help to mask bitter taste of propranolol. All formulations were evaluated for their weight variation, thickness, folding endurance, tensile strength, & percentage elongation, surface pH, percentage drug content, in vitro disintegration time, dissolution. Formulations F8 and F9 formulations release 97.21% and 96.89% of drug in 12min & F1, F2 and F5 formulation less than 90% of drug release in 12 min.

Keywords: Fast dissolving oral film, HPMC, Maltodextrin, polymers, solvent casting method.


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