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Abstract

REVIEW ARTICLE

*Shilpi Arora

ABSTRACT

Pulsatile drug delivery systems are gaining a lot of interest as they deliver the drug at the site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in increasing patient compliance. These systems are turned according to body‘s circadian clock having a potential to improve quality of patients life undergoing conventional therapy. Various systems like capsular systems, osmotic systems, single and multiple unit systems are based on the use of soluble or erodible polymer coating rupturable membranes and membrane permeability have been used. Many of circadian dependent diseases display acute symptoms in early morning hours or in the morning at awakening. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Now in market varies technologies of pulsatile drug delivery system like Pulsincap, Diffucaps Codas etc. are launched by pharmaceutical companies. Circadian behaviour in glucose and insulin secretion in diabetes was revealed and studied. Increase in blood sugar level is found after meal. Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia resulting from defects of insulin secretion and or increased cellular resistance to insulin.

Keywords: PDDS, Chronopharmacotherapy, Lag Time, Circadian Rhythms, Diabetes Mellitus.


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