Abstract

COMPARISON OF YIELD PERCENTAGE BY 2nd ORDER REACTION KINETICS IN SYNTHESIS OF PIPERAZINE MOIETIES BY GREEN SOLVENTS AND IONIC LIQUID

*Viraj P. Jatakiya, Nadim M. R. Chhipa and Prof. Dr. Dhrubo Jyoti Sen

ABSTRACT

N-ethyl piperazine has been conjugated with substituted aromatic acid chlorides in J-1 to J-3 series and in J-4 with higher homologous unsubstituted acid chloride and then converted in to Schiff’s base by substituted aromatic amines by conventional method (methanol) and green solvents (1-butanol and ionic liquid: triethyl methyl ammonium methyl sulphate). Rate of reaction was tested for all compounds by kinetic study and all compounds were characterized by spectral studies. Final compounds % yield in methanol was found around 88%, in 1-butanol around 66% and in ionic liquid above 99%. Overall rate of reaction was found 2 nd order in kinetic study. Rate of reaction k in methanol was found = 0.0004 μg-1sec-1and in 1-butanol it was = 0.0001 μg-1sec-1, half life of reaction was 250 seconds in methanol and 1000 seconds in 1-butanol while overall reaction time in ionic liquid was only 20 seconds. % yield and rate of reaction is highest in ionic liquid compared to other two solvents, so reaction is more ecofriendly and more acceptable in this environmental benign solvent.

Keywords: N-ethyl piperazine, Schiff’s base, Green solvents, Ionic liquids, Reaction kinetics, Half-life.