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Abstract

IMMUNOMODULATORY ACTIVITY OF ETHANOLIC EXTRACT OF IVY GOURD [Coccinia grandis (L.) Voigt] LEAVES ON BALB/c MICE

Khoriyoh Baha* and Maria Immacutala Iwo

ABSTRACT

Ivy gourd [Coccinia grandis (L.) Voigt] is a tropical plant widely distributed throughout Asia, Africa, and Pacific Island. The immunomodulatory effect of this plant has not been proven scientifically. The aim of this work was to study the immunomodulatory effect of ethanolic extract of ivy gourd leaves (EEIL) against the immune response in BALB/c mice. The EEIL was administered orally at the doses of 200 (D1), 100 (D2) and 50 (D3) mg/kg bw of mouse. The assessment of immunomodulatory activity on non-specific immunity was determined by carbon clearance test and organ index, while specific immunity by delayed type hypersensitivity (DTH) test, heamagglutination antibody (HA) titer and cytokines level. The immunomodulatory efficacy of the extract was tested on Salmonella typhimurium infected mice. Results showed that D1 and D2 of the extract showed a significant increased (p<0.05) in phagocytic index in carbon clearance test. The liver index of D1 increased significantly (p<0.05) compared to control. Delayed-type hypersensitivity test showed the increase of mice footpad thickness significantly (p<0.05) in D1 and D2. The EEIL also increased in primary and secondary antibody production. The IFN- γ level of D1 increased significantly (p<0.05) but IL-2 level of all groups were not affected. S. typhimurium infected mice showed improvement in clinical findings. The administration of EEIL showed repairment of damaged liver of S. typhimurium infected mice and non – toxic against the liver which can be seen in the increase of albumin and total protein levels and a decrease of SGPT level. It was also non – toxic against the kidney as verified with no change in creatinine level. The study demonstrates that the ethanolic extract of ivy gourd leaves possesses immunomodulatory effect with immunostimulatory activity.

Keywords: Immunomodulatory activity, non – specific immunity, specific immunity, Coccinia grandis (L.) Voigt.


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