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  • MARCH 2019 Issue has been successfully launched on 1 March 2019

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Manuel Aparicio-Razo, María del Rosario Leticia Cabrera-Lara, Germán Barrientos-Cabrera, Laura Contreras-Mioni, Angel Vladimir Ibañez Barzalobre, Jesús Alejandro Martínez Juárez, Oscar Sánchez Parada and *Manuel González Pérez


Toxoplasma gondii (TG), a Protozoan parasite intracellular, which causes disorders that affects the brain and has been linked to the disease of schizophrenia. Infection with Toxoplasma gondii stimulates the degradation of tryptophan and is involved in producing neurodegenerative metabolites such as the kynurenic acid. The objective of the study is to determine, using the quantum semi-empirical method parametric (SE-PM3/1), which neurotransmitter has a higher affinity with the acid kynurenic, so understanding the neuronal oxidative effect. Hyperchem Professional software performed Molecular Modelling and analysis of the molecules of cGMP/AMPc and 9 of the major neurotransmitters. (Hyperchem, Hypercube, Multi on for Windows, series 12-800-1501800080. Multi On, southern 1236 -301 Tlacoquemecatl insurgent Col. del Valle, Mexico, Benito Juárez, CP 03200). The result of simulations of quantum wells reveals that this metabolite is a likely media, which can oxidize the neurotransmitter Adrenaline.

Keywords: Neurotransmitters, Toxoplasma Gondii, Quantum Method, Hyperchem, SE-PM3.

[Full Text Article]

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