WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

PREPARATION AND EVALUATION OF LOSARTAN POTASSIUM MUCOADHESIVE MICROSPHERES

Nethaji Ramalingam*, Binulal C., Manikandan Palanivelu and Babu Ganesan

ABSTRACT

The present study deals with Losartan potassium Mucoadhesive microspheres formulation using sodium alginate, carbopol 934 and sodium carboxy methyl cellulose by ionic gelation technique with an aim to prolonged and sustained the drug release with an improve the bioavailability. Ten formulations were prepared by using different in drug to polymer ratios, and evaluated the relevant parameters. The percentage yield of all the formulations is found between 64.61% to 88.44%. The surface morphology of the formulated microspheres was characterized by SEM and it was discrete, spherical in shape and showed free flowing properties. The mean particle size of the microspheres is range between 134.4μm to 197.6μm. Among all the formulations, LP6 showed high drug entrapment efficiency (65.76%), highest percentage swelling index (84.76%) and lowest percentage moisture loss (7.68%). The in-vitro wash-off test indicated that the microspheres were shown good mucoadhesive properties. The in-vitro drug release studies revealed that LP6 formulation shown sustained effect and it was found to be 77.91% at the end of dissolution studies. The mechanism of drug release was also evaluated using the linear regression coefficient according to the various kinetic models which to found goodness of fit. Stability studies of selected formulations showed good results. It could be conclude that all formulated microspheres were shown satisfactory results and suitable for the gastro retentive drug delivery system (GRDDS) for potential therapeutic uses.

Keywords: Losartan Potassium, Mucoadhesive Microspheres, Carbopol 934, Sodium carboxy methyl cellulose, in-vitro evaluation, Stability studies.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More