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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

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Abstract

STABILITY IDICATING RP-UHPLC METHOD FOR SIMULTANEOUS DETERMINATION OF OFLOXACIN AND ORNIDAZOLE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Himakshi Baishya, Barnali Gogoi, Ripunjoy Bordoloi* and Dr. Parthajyoti Gogoi

ABSTRACT

A simple, stable, economic, accurate, precise and robust reverse phase ultra high pressure liquid chromatography (RP-UHPLC) method was developed and validated for simultaneous estimation of Ofloxacin and Ornidazole in pharmaceutical dosage form. The UHPLC separation was achieved on Agilent C18 column (150 mm x 4.6 mm id, 5 μ particle size) with isocratic condition at ambient temperature using mobile phase as a buffer (2.72 g of potassium dihydrogen phosphate in 1000ml of water and adjust the pH to 2.4 with Orthophosphoric acid): Acetonitrile in the ratio (80:20 v/v). The analysis was performed at flow rate 2 ml/min. Separation was achieved with UV detection at 294 nm. Retention time of Ofloxacin and Ornidazole were found to be 3.068 ± 0.20 minute and 4.955 ± 0.20 minute respectively. The linearity was studied in the concentration range 40-200 μg/ml and 100-500 μg/ml for Ofloxacin and Ornidazole respectively. The assay was validated for the parameters like system suitability, linearity, accuracy, precision, robustness, LOD & LOQ.

Keywords: RP-UHPLC; Ofloxacin; Ornidazole; Method Validation.


[Full Text Article]

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