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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DEVELOPMENT OF NOVEL UV SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF TASIMELTEON

Utkarsha V. Naik*, Dr. Milind J. Umekar and Radheshyam T. Lohiya

ABSTRACT

A simple, accurate, precise, rapid analytical methods for the estimation of Tasimelteon in bulk. The λmax of tasimelteon in acetonitrile and Double distill water (50:50) was found to be 225.0 nm. All five methods of UV-Spectrophotometry based upon Zero Order, First Order and Second Order derivative have been established considering amplitude and Area under curve of the spectrum. In all five method, Tasimelteon obeyed linearity in the concentration range of 4-20 μg/mL with correlation coefficient 0.999. All the methods were validated as per International conference on Harmonization (ICH) guidelines. All these proposed methods were proved to be linear, accurate, precise and rugged and also adequately sensitive.

Keywords: Tasimelteon, Acetonitrile, UV-Visible spectroscopy.


[Full Text Article]

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