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  • WJPPS SEPTEMBER ISSUE PUBLISHED
  • SEPTEMBER 2018 Issue has been successfully launched on 1 September 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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Abstract

DESIGN, In-vitro AND In-vivo EVALUATIONS OF CLARITHROMYCIN BIOADHESIVE TABLETS FOR PEPTIC ULCER

Nishad K. M.*, Girendra Gautam, Rajasekaran S., Ibrahim Afsal V. T. and Rashid K.

ABSTRACT

The present study of this research work was to formulate bioadhesive tablets of clarithromycin for the treatment of gastric ulcers caused by H. pylori bacteria. Clarithromycin is a semisynthetic macrolide antibiotic for the treatment of peptic ulcer. The tabets were formulated by synthetic polymer by carbopol- 934 for controlled drug delivery of 24 hrs. The drugs and excipients were subjected to compatibility studies using FTIR. The in process evaluation studies were performed for tablet processing. The formulated and selected tablets were performed for in- vitro dissolution studies. Adhesive properties of polymers and tablets were confirmed by ex vivo methods. The duration of binding were determined by pre-clinical studies in rabbits as in- vivo methods. The tablets were subjected to stability studies. The study finally concluded that clarithromycin bioadhesive tablets loaded by carbopol 934 polymer is a good controlled release tablets for mucoadhesion due to good release retarding mechanism and carbopol 934 is synthetic polymer for binding action.

Keywords: Clarithromycin, mucoadhesion, carbopol -934, Ex-vivo methods, in- vitro studies, in -vivo studies, X - ray imaging technique.


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