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  • WJPPS JULY ISSUE PUBLISHED
  • JULY 2018 Issue has been successfully launched on 1 July 2018

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  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from 6.647 to 7.421 due to high quality Publication at International Level

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  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

FORMULATION AND EVALUATION OF BUCCAL PATCHES OF DICLOFENAC SODIUM

Mamatha G. T.*, Divyashree K., Hashmi Udayan, Jishnu V. A. and Neena Jose

ABSTRACT

In the present study was an attempt to formulate and evaluate the Buccal patches of diclofenac sodium. Buccal patches were prepared by solvent casting technique using different concentration of polymer, hydroxy propyl methyl cellulose (HPMC) and sodium starch glycolate as superdisintegant, using plasticizers, permeation enhancers, saliva stimulating agent and sweetener were added. Patches were evaluated for weight variation, thickness, drug content, folding endurance and vitro drug release. All formulated patches were shown satisfactory results which complies with an official limits. The results shown the formulation exhibited acceptable drug content, film thickness, folding endurance, surface pH and swelling index.The results revealed that 4% sodium starch glycolate (F5) was found to be more promising in vitro drug release of prepared diclofenac sodium baccal patches. It can be concluded that diclofenac buccal patches offer more stable, predictable and faster drug release/absorption at higher concentration of sodium starch glycolate.

Keywords: Buccal patch, diclofenac sodium, HPMC, sodium starch glycolate.


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