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  • FEBRUARY 2019 Issue has been successfully launched on 1 February 2019

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K. Anitha*, Ruquia Siddiqa, Shareefa Unnisa Begum, Saleha Fatima, Yasmeen Begum and Nikhath Siddiqua Shaik


The objective of the study was to formulate and evaluate orally disintegrating tablet of orlistat. Direct compression method was used to formulate orally disintegrating tablet of orlistat by employing different superdisintegrants, polymers, and magnesium stearate (lubricant), Talc. These prepared formulations were then evaluated. Dissolution and drug content tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. All formulations showed compliance with pharmacopeia standards. The effect of superdisintegrants concentration and direct compression method on drug release profile was studied. Release profile of F3 were found to be satisfactory comparing to other formulations. F3 Formulation as processed excipient was found to be the best superdisintegrants for the preparation of orlistat orally disintegrating tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations.

Keywords: Orlistat, superdisintegrants, natural and synthetic polymers, direct compression technique, in-vitro drug release studies.

[Full Text Article]

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